Research in the Stagg lab is directed towards two tracks: the mechanisms of membrane trafficking, and high-throughput high-resolution cryo-EM. On the biological side, we determine the structure and mechanisms of medically relevant protein complexes involved in vesicle trafficking pathways. We have determined structures of COPII and clathrin coats as well as other membrane remodeling complexes. On the technical side, we develop experimental and computational methods to improve structure determination by cryo-EM.