The Yin lab is interested in discovering the molecular mechanisms of individual proteins and protein assemblies in innate immunity, host-pathogen interactions, and membrane trafficking. Recent focus is on the endomembrane system, which is the focal point of both antimicrobial defense and cell homeostasis. Yin lab uses X-ray crystallography and cryo-EM, together with other biochemical and biophysical tools, to reveal the intricacies of complex biological processes.