BCH 4053 Syllabus

Summer, 2004

 

Instructor:    Dr. Timothy M. Logan

                      Office: 502 KLB; Phone 644-8979; e-mail: logan@sb.fsu.edu

                      Web page: http://www.sb.fsu.edu/~logan

Textbook:  Biochemistry 2nd edition.  Garrett & Grisham, authors.  In the book store.

Course Objective:  BCH 4053 is the first course in a two-semester sequence in biochemistry for advanced undergraduates and beginning graduate students.  The course provides a comprehensive survey of the major topics in biochemistry, with the objective being to develop the tools necessary to understand biological processes in chemical terms.  Experience has shown that nothing in this course is conceptually challenging.  However, this is a very  difficult course because of the large volume of material covered.  DO NOT FALL BEHIND!

Prerequisites:  Prerequisite for this course is one year of organic chemistry, but I will assume some familiarity with thermodynamics and reaction kinetics, as well as some biology.  Those stu­dents that have not completed the prerequisites must check with the instructor and will be held responsible for the background material.   Note that I teach this as a Chemistry course, not a Biology course.  Chemical concepts will be stressed.

Office Hours:  My office hours will be from 11-12 noon MWF.  Some of you will have conflicts with those times so I will also be available by appointment (my phone number and e-mail are listed above).  These sessions are not intended to be a private tutorial for material missed in class.  Please come to my office with specific, prepared questions so that both of our times will be used effectively.

Grading:  There will be four hour exams during the semester, each worth 100 points.  The exams will take place during normal class hours. You may drop the lowest hourly test score from your grade, so there will be no make up exams - no exceptions! Exam dates listed in syllabus are approximate and may vary by ± 1 lecture.  Any variation from the syllabus will be established in class at least one week prior to each exam. I will not assign and collect weekly homework problems.  Some additional homeworks may be given throughout the semester that will count as extra credit points to your exam scores and be factored into your final grade.  These problems will be more integrative and will require more thought than the homeworks at the back of each chapter.  You may work in a group, if you wish, but all group members must sign their names to the homework problem and all will receive the same grade for that homework.

Attendance:  Your presence in class is important, and practical experience shows that your final grade is directly proportional to attendance.  I will be lecturing from the assigned text, but I may include additional material in my lectures that is not in the book.  You will be responsible for all material in the text and presented in class for the exams.

Academic Honor Code:  I remind each of you that you are bound by the Academic Honor Code.  Please review the section titled “Academic Honor System” in your FSU Student Handbook.
Approximate Lecture / Exam Schedule

Lect.    

Date

Topic

Chapter

1

M

5/10

Introduction;  Water Solutions

1,2

 

2

W

5/12

Acids and Bases, pH & Buffers

2

 

3

F

5/14

Biochemical Thermodynamics

2

 

4

M

5/17

Coupled Reactions, Group Transfer potentials

3

 

5

W

5/19

Amino Acids, peptides

4

 

6

F

    5/21

Peptide Bonds, peptide titrations

4

 

7

M

    5/24

Peptide & protein purification

5

 

8

W

5/26

Sequencing peptides

5

 

 

F

5/27

Exam I

2-5

 

 

M

5/31

Memorial Day Holiday, no classes

 

 

9

W

6/2

Protein Secondary Structure

6

 

10

F

6/4

Tertiary Structures and Protein Families

6

 

11

M

6/7

Protein Folding

6

 

12

W

6/9

Carbohydrates

7

 

13

F

6/11

Lipids and Membranes, transport

8,9

 

14

M

6/14

Membrane Transport, Nucleic Acids

10,11

 

15

W

6/16

DNA sequencing, structure

10

 

16

F

6/18

A, B, Zs of DNA structure; RNA structure

11

 

 

M

6/21

Hour Exam 2                                                                               

6-11

 

17

W

6/23

Enzymes and Catalysis; Enzyme kinetics

13

 

18

F

6/25

Enzyme Inhibition; Enzyme Regulation

13

 

19

M

6/28

Allosteric Regulation; Myoglobin and Hemoglobin                                                        

14

 

20

W

6/30

Enzymes and Catalysis;Enzyme kinetics

14

 

21

F

7/2

Enzymes and Catalysis;Enzyme kinetics

15

 

22

M

7/5

July Fourth Holiday, no classes

 

 

23

W

7/7

Hill Plots and Cooperativity

14

 

24

F

7/9

Transition States; Mechanisms of Catalysis

15

 

 

M

7/12

Exam 3

13-15

 

25

W

7/14

Introduction to Metabolism; Glycolysis

17

 

26

F

7/16

Glycolysis; Anaerobic Pyruvate Metabolism

18

 

27

M

7/19

Regulating Glycolysis; Aerobic Metabolism of Pyruvate

18

 

28

W

7/21

TCA cycle

19

 

29

F

7/23

Anaplerotic Reactions; Glyoxylate Shunt

19

 

 

M

7/26

Exam 4

17-19

 

30

W

7/28

Redox Reactions and Free Energy Changes

20

 

31

F

7/30

Electron Transport

21

 

32

M

8/2

Electron Transport,Phosphorylation; Chemiosmotic Theory

21

 

33

W

8/4

ATP synthesis

21

 

 

F

8/6

Summary (Summery?) Exam

Cummulative