Electron Transfer in Sulfite Reductase

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Sulfite Reductase (SiR) is responsible for the six-electron reduction of sulfite to sulfide, a six-electron reduction. It is composed of two subunits, a hemoprotein and a flavoprotein, that work together with their resident cofactors to move electrons from the cytoplasm to the substrate. We aim to understand how the proteins work with their cofactors to perform this rich, complex chemical transformation.

 

The Molecular Basis of Gene Expression

NDPK

Genetic information comes to life when a DNA molecule is transcribed into a messenger RNA molecule before being translated into protein. In eukaryotes, special sequences of DNA help control how and when genes are transcribed. Once in the cytoplasm, resulting mRNA molecules are translated into proteins by the ribosome. The goal of our research is to understand the structural basis for regulating non-Watson-Crick DNA structures called guanine quadruplexes that help control the flow of genetic information in the nucleus. We are also studying how the small subunit of the the ribosome is assembled, focusing on understanding how structural heterogeneity affects function.

 

The lab uses a combination of x-ray crystallography and cryo-EM to determine the structure and function of these important biomolecules.

FSU’s Biological Science Imaging Resource is the home of a state-of-the art cryo-TEM called the Titan Krios, one of only a few in the world.

Lab News
  • 1/30/17 Congratulations to Isabel on being nominated for a Teaching award for her hard work last semester!
  • 1/20/17 another Stroupe lab publication in collaboration with the Karbstein group at Scripps-FL.  http://www.cell.com/structure/pdfExtended/S0969-2126(16)30401-4
  • 11/15/16 Congratulations to Joe on successfully defending his proposal!
  • 4/29/16 Two new Stroupe Lab Graduates - Trevia Jackson is on to Medical School and Rachel will join the lab as our cloning genius while she prepares her graduate school applications!  And yeah - those cards are Garnet and Gold!
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  • 4/6/16 Congratulations to Rachel Andrews, the next Stroupe Lab Honors in the Major graduate!
  • 11/30/15 Congratulations to Isabel Askenasy on successfully defending her proposal and to Trevia Jackson on successfully defending her Honors in the Major thesis!  Henry Sparkles says "Good Job!".
  • 7/1/15 Another Stroupe Lab manuscript (Askenasy, Pennington et al JBC 2015)
  • 5/10/15 Not only is Mike K smart, he is also clever! check out his contribution to PhD comics! http://phdcomics.com/comics/archive.php?comicid=1798
  • 5/1/15 Congratulations to Marisa Cepeda, 2015 recipient of the Delos F. DeTar and Francis F. DeTar Scholarship in Chemistry!  Good job and have a super summer internship!
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  • 4/28/14 Thank you to Trevia Jackon for nominating me for the Outstanding Undergraduate Research Mentor Award - the support of the whole lab in writing the application was wonderful!
  • 3/27/14 Congratulations to the newest Stroupe lab member, Joe Pennington, on being awarded FSU's Auzenne Wilson Graduate Fellowship for 2014-2015!
  • 3/3/14 Another paper - and the cover! Stroupe et. al.
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  • 9/12/13 Read the latest research article from the StroupeGroup - Sousa et. al.
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  • 9/1/13 Congratulations to Isabel Askenasy, Candidate for PhD!
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  • 8/1/13 Congratulations to Kyle Smith, Rice University's newest Chemistry Graduate Student!