Professional Publications of Thayumanasamy Somasundaram

Journals and Book Articles

32.’The structure of lombricine kinase: implications for phosphagen kinase conformational changes‘, D .J. Bush, O. Kirillova, S.A. Clark, O. Davulcu, F. Fabiola, Q. Xie, Thayumanasamy Somasundaram, W.R. Ellington, and M.S. Chapman. J. Biol Chem. M110 .202796, (2011).

31.’De-icing: Recovery of Diffraction Intensities in the presence of Ice Rings‘, Michael Chapman and Thayumanasamy Somasundaram. Acta Cryst. D66, 741-744 (2010).

30.’ Spackling the crack: stabilizing human fibroblast growth factor-1 by targeting the N- and c- terminus β-strand interactions‘ Vikash Kumar Dubey , Jihun Lee, T. Somasundaram, Sachiko Blaber, and M. Blaber. J. Mol. Biol. 371(1), 256-268 (2007). [DOI Link]

29.’ Conversion of type I 4:6 to 3:5 ß-turn types in human acidic fibroblast growth factor ‘, Jihun Lee, Vikash Kumar Dubey , T. Somasundaram, and M. Blaber. Proteins: Structure, Function, and Bioinformatics 62(3), 686-697 (2006). [DOI Link]

28.’ An atomic resolution structure for human fibroblast growth factor 1 ‘, Matthew J. Bernett, T. Somasundaram, and M. Blaber. Proteins: Structure, Function, and Bioinformatics 57(3), 626-634 (2004). [DOI Link]

27.’ The putative catalytic bases have, at most, an accessory role in the mechanism of arginine kinase ‘, P.S. Pruett, A. Azzi, S.A. Clark, M.S. Yousef, J.L. Gattis, T. Somasundaram, W.R. Ellington and M. S. Chapman. J Biol Chem 278(29), 26952-57 (2003). [DOI Link]

26.’ Structure determination of adeno-associated virus 2: three complete virus particles per asymmetric unit ‘, Q. Xie, T. Somasundaram , S. Bhatia, W. Bu and M. S. Chapman. Acta Cryst D59(6), 959-970 (2003). [DOI Link]

25.’ Induced fit in guanidino kinases-Comparison of substrate-free and transition state analog structures of arginine kinase ‘, M.S. Yousef, S. A. Clark, P. K. Pruett, T. Somasundaram , W. R. Ellington and M. S. Chapman. Protein Sci 12(1), 103-111 (2003). [DOI Link]

24.’ Refinement of the arginine kinase transition-state analogue complex at 1.2 A resolution: mechanistic insights ‘, M.S. Yousef, F. Fabiola, J.L. Gattis, T. Somasundaram , and M. S. Chapman. Acta Cryst D58(12), 2009-2017 (2002). [DOI Link]

23.’ The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy ‘, Q. Xie, W. Bu, S. Bhatia, J. Hare, T. Somasundaram , A. Azzi, and M. S. Chapman. Proc Natl Acad Sci (USA) 99(16), 10405-10410 (2002). [DOI Link]

22.’ Polylysine induces an antiparallel actin dimerthat nucleates filament assembly: Crystal Structure at 3.5-A resolution ‘, M.R. Bubb, L. Govindasamy, E.G. Yarmola, S.M. Vorobiev, S.C. Almo, T. Somasundaram, M.S. Chapman, M. Agbandje-McKenna, and R. McKenna. J Biol Chem 277(23), 20999-21006 (2002); PIP M201371200 April 3, 2002. [DOI Link]

21.’ Actin-latrunculin A structure and function ‘, E. G. Yarmola, T. Somasundaram, T. A. Boring, I. Spector, and M. R. Bubb, J Biol Chem 275(36), 28120-28127 (2000). [DOI Link]

20.’ Critical initial real-space refinement in the structure determination of arginine kinase‘, G. Zhou, T. Somasundaram, E. Blanc, Z. Chen, and M. S. Chapman, Acta Cryst D55 (4), 835-845 (1999). [DOI Link]

19.’Transition State Structure of Arginine Kinase: Implications for catalysis of bimolecular reactions‘, G. Zhou, T. Somasundaram, E. Blanc, G. Parthasarathy, W. R. Ellington, and M. S. Chapman, Proc Natl Acad of Sci(USA) 95 (15), 8449-8454 (1998).

18.’Expression, Purification from Inclusion Bodies, and Crystal Characterization of a Transition State Analog Complex of Arginine Kinase: a Model for Studying Phosphagen Kinases‘, G. Zhou, G. Parthasarathy, T. Somasundaram, A. Ables, L. Roy, S. J. Strong, W. R. Ellington, and M. S. Chapman, Prot Sci 6, 444-449 (1997).

17.’Methane-induced hemolysis of human erythrocytes‘, H. F. Batliwala, T. Somasundaram, E. E. Uzgiris, and L. Makowski, Biochem J 307, 433-438 (1995).

16.’Optical cell for the study of biological systems under high gas pressures‘, T. Somasundaram, and L. Makowski, Rev Sci Instrum 66, 3311-3316 (1995).[DOI Link]

15.’Binding site conformation dictates the color of the dye stains-all‘, Y. Sharma, Ch. M. Rao, S. C. Rao, A. G. Krishna, T. Somasundaram, and D. Balasubramanian, J Biol Chem 264, 20923-20927 (1989).

14.’Calcium ion binding to d- and b-crystallins‘, Y. Sharma, Ch. M. Rao, M. L. Narasu, S. C. Rao, T. Somasundaram, A. Gopalakrishna, and D. Balasubramanian, J Biol Chem 264, 12794-12799 (1989).

13.’The importance of an adsorbed liquid layer for the enhancement of photoacoustic signals‘, P. Ganguly and T. Somasundaram, in ” Photoacoustic and photothermal phenomena”, Eds. P. Hess and J. Pelzl, Springer Series in Optical Sciences, v. 58, pp. 316-320, Springer-Verlag, Berlin, 1988.

12.’Influence of flowing gases on the amplitude of gas-microphone detected photoacoustic signals from porous and nonporous solids‘, P. Ganguly and T. Somasundaram, in ” Photoacoustic and photothermal phenomena , Eds. P. Hess and J. Pelzl, Springer Series in Optical Sciences, v. 58, pp. 333-334, Springer-Verlag, Berlin, 1988.

11. ‘In situ photoacoustic spectroscopic studies of heterogeneous catalysts under conditions of gas flow‘, T. Somasundaram and P. Ganguly, Bull Mater Sci 9, 81-87 (1987).

10.’Experiments with flowing gases in an open photoacoustic cell‘, P. Ganguly and T. Somasundaram, Proc Indian Acad Sci (Chem Sci) 98, 305-309 (1987).

9.’Quantitative estimation of substances spotted on filter paper by photoacoustic spectroscopy‘, T. Somasundaram, S.S.R. Rao, and P. Ganguly, Proc Indian Acad Sci (Chem Sci) 98, 171-176 (1987).

8. ‘Determination of acidities of zeolites by photoacoustic spectroscopy’, T. Somasundaram, P. Ganguly, and C.N.R. Rao, Zeolites 7, 404-407 (1987).

7. ‘Studies on the enhancement of photoacoustic signals from non-porous solids in presence of volatile liquids’, P. Ganguly and T. Somasundaram, Appl Phys B43, 43-52 (1987).

6. ‘Photoacoustic investigation of phase transition in solids‘, T. Somasundaram, P. Ganguly, and C.N. R. Rao, J Phys C: Solid State Phys 19, 2137-2151 (1986).[DOI Link]

5. ‘Investigation of solids and surfaces by photoacoustic spectroscopy’, C.N.R. Rao, P. Ganguly, and T. Somasundaram, J Indian Chem Soc 63, 1-9 (1986).

4. ‘Enhancement of photoacoustic signals from condensed materials in the presence of volatile liquids: Influence of optical absorption coefficient,particle size, length of gas phase, and chopping frequency‘, T. Somasundaram and P. Ganguly, J Appl Phys 57, 5043-5047 (1985). [DOI Link]

3. ‘Influence of adsorbed vapors on the photoacoustic spectra of liquids, T. Somasundaram and P. Ganguly, J Colloid Interface Sci 101, 579-582 (1984). [DOI Link]

2. ‘A novel technique for enhancing photoacoustic signals from solids‘, P. Ganguly and T. Somasundaram, Appl Phys Lett 43, 160-162 (1983). [DOI Link]

1. ‘Photoacoustic spectra of As2S3-As2Se3 glasses‘, T. Somasundaram, P. Ganguly, and K.J. Rao, Proc Indian Acad Sci (Chem Sci) 92, 65-71 (1983).

Invited Talks

7.Core Facilities: Challenges and Opportunities‘, T. Somasundaram. 2018 PITTCON Conferee Networking Event, Orlando, Florida, Feb 26, 2018.

6.Low-cost home-built imager for protein screening‘, T. Somasundaram. 66th Annual Meeting, American Crystallographic Association, Denver, CO, Jul 22-26, 2016.

5.Funding/Upgrading for Mid-size Equipment‘, T. Somasundaram. 2016 PITTCON Conferee Networking Event, Atlanta, Georgia.

4. ‘Why you need a home X-Ray Facility?‘, T. Somasundaram. 2015 Second Florida Core Networking Event, Moffitt Cancer Center, Tampa, Florida.

3. ‘FSU’s IMB Core Facilities and their capabilities‘, T. Somasundaram. 2014 First Florida Core Networking Event, UF-ICBR, Gainesville, Florida.

2. ‘Effective Communication in the world of Shared Resources‘, T. Somasundaram. 2013 First Annual Southeastern Association of Shared Resources, UGA, Athens, Georgia.

1. ‘ Cryo Crystallography at SynchrotronsT. Somasundaram, 2007 Florida Chapter of AVS Science and Technology Society and FSM, UCF, Orlando, Florida,

Symposium/Posters

18. ‘Improved Robotic Imager’,  T. Somasundaram and M. Zawrotny2018 Pittcon, Orlando, FL; Feb 25-27, 2018.

17. Dual and mono axis robotic crystal imager‘, M. Zawrotny and T. Somasundaram, 2017 FSU CoM Life Sciences Symposium, Tallahassee, FL 32306; Feb 9-10, 2017 [html | pdf].

16. Simple Imager for Multi-well Plates‘, M. Zawrotny and T. Somasundaram, 2016 Pittcon, Atlanta, GA 30313; Mar 8, 2016.

15. Simple Robotic Imager for Multi-well Plates‘, M. Zawrotny and T. Somasundaram, 2016 Life Science Symposium, FSU College of Medicine, Tallahassee, FL 32306; Feb 25-26, 2016.

14. ‘IMB XRF-Core Facility’, T. Somasundaram, 2015 Fifth Annual Life Science Symposium: Ageing, Tallahassee, FL. Feb 19-20, 2015.

13. ‘FSU’s IMB Core Facilities’, C. Mundoma, J. Hare and  T. Somasundaram. 2014 First Florida Core Network Event, ICBR-UF, Gainesville, FL, Aug 15, 2014.

12. ‘FSU Core Facilities: Biophysical Cores‘, D. Sousa, B. Chen, C. Mundoma, and T. Somasundaram. 2014 Fourth Annual Life Sciences Symposium: Frontiers in Biomolecular Communication, Tallahassee, FL, Feb 13-14, 2014.

11. ‘The Cellular prion protein octarepeat region as a recognition motif for hemin binding‘, E. Artikis, W.E. Johnson, T. Somasundaram, E.A. Bienkiewicz, Prion 2013: Prion, 7, Suppl. 1, 2013 [http://www.tandfonline.com/doi/pdf/10.4161/pri.24866]

10. ‘Development of a vascular injury therapeutic agent’, E. Artikis, W. Johnson, T. Somasundaram, and E. Bienkiewicz, 8th Annual Research Fair, College of Medicine, FSU, Tallahassee, FL. Feb 14, 2012.

09. ‘ Structure determination of Adeno-associated virus 2 in P1 cell with three complet e virus particles.‘, Q. Xie, T. Somasundaram , S. Bhatia, W. Bu, M. S. Chapman. 2003 Annual American Crystallographic Association Meeting, Covington, KY.

08. ‘ Classical enzymology at atomic resolution – Substrate alignment and induced fit‘, M. S. Chapman, M. Yousef, S. A. Clark, P. Pruett, A. Azzi. J. Gattis, F. Fabiola, T. Somasundaram , and W. R. Ellington. 2002 IUCr XIX Congress, Geneva, Switzerland.

07. ‘ Structure of an anti-parallel action dimer‘, C. Banchs, M. Bubb, L. Govindasa my, E. Yarmola, T. Somasundaram , M. Chapman, S. Vorobiev, S. Almo, M.A-McKenna, R. McKenna. 2002 Annual American Crystallographic Association Meeting, San Antonio, Texas.

06. ‘ X-ray structure of apo-2,5-di-keto-D-gluconic acid reductase‘, G. Sanli, T. Somasundaram, M. Blaber, 45th Biophysical Society Meeting, Feb. 17-21, 2001, Boston, MA. 257- Poster, B# 113 (2001).

05. ‘ Catalysis in arginine kinase investigated through structure, mutagenesis, and kinetics‘, P. Pruett, A. Azzi, J. G. Gattis, T. Somasundaram, W.R. Ellington, M.S. Chapman, ACA 2000 Annual Meeting. Abstract # W0078 (2000).

04. ‘ Orbital Steering and Entropy: A Bimolecular Phosphoryl Transferase Transition State Analog at 1.8 Å Resolution‘, J. L. Gattis, G. Zhou, P. S. Pruett, T. Somasundaram, W. R. Ellington, M. S. Chapman, ACA 1999 Annual Meeting. S0207, Abstract # W0120 (1999).

03. ‘Transition state structure of arginine kinase: Implications for catalysis of biomo lecular reactions‘, M. S. ChapmanS. Chapman, G. Zhou, T. Somasundaram, E. Blanc, G. D. Parthasarathy, and W. R. Ellington. 1998 American Crystallographic Society Meeting, Arlington, VA. Abstract E0090 (1998).

02. ‘The effect of small hydrophobic gas molecules on detergent-induced hemolysis‘, H. Batliwala, T. Somasundaram, E. Uzgiris, and L. Makowski, 36th Annual Biophysical Society Meeting, Houston, TX, 1992. Biophys. J. 61 , A79 #457 (1992).

01. ‘A novel technique for the enhancement of photoacoustic signal’, T. Somasundaram and P. Ganguly, Third International conference on photoacoustic and photothermal spectroscopy, Paris, 1993. J Phys Colloq 44, C6: 239-242 (1983).

 

Awards

  • ‘2017 Prudential Productivity Cash Award’ FSU ID#: 404– William Sweeney, Thayumanasamy Somasundaram, Claudius Mundoma, James Stephens, Donna Trumbower, Carlos Murphy, Kyle Gower-Winter, and Rebekah Dorn, Scientific Equipment Database and Web Portal, Jun 14, 2017.

Professional Service

  1.  Mentor, Young Scholars Program of Department of Biological Science, FSU (2007-present)
  2.  Organizer, Florida Core Network Event 3, Florida State University, August 2016
  3.  Judge, Capital Regional Science & Engineering Fair, Feb 13, 2015; Feb 12, 2016
  4.  Treasurer, Southeastern Association of Shared Resources, 2016-2019
  5.  Co-Supervisor,  Arts In Community Engagement, Art Education, 2014-present
  6.  Poster Judge, ACA 2014 Annual Meeting, Albuquerque, NM.
  7.  Safety Coordinator, Student safety training with FSU Safety Office, (2008–present)
  8.  Communication member, FSU-Wide Core Facility Managers Network (2012-present)

Journal club

13. ‘Annual SER-CAT Meeting Program‘, Tenth Annual SER-CAT Meeting Program, 2013.
12. ‘XRF one of FSU-RFs‘, FSU Research Facility Network Meeting, 2012.
11.’Research Facility Network‘, FSU Research Facility Network Meeting, 2012.
10. ‘XRF FAMU Tour‘, FAMU Student Visitors Presentation, 2011.
09. ‘XRF Student Tour‘, Graduate Student Orientation Tour, 2010.
08. ‘IMB Orientation for newcomers‘, New-user Orientation, 2009.
07.’MOB XRF Overview‘, XRF Core Facility Overview Presentation, 2008.
06. ‘What X-Ray Facility Can Do for You?‘ , MOB Orientation Presentation, 2007.
05. ‘Kasha Lab Etiquettes‘, Orientation Presentation, 2006.
04. ‘X-Ray Facility Data Archiving and Extraction‘, Journal Club Presentation, 2005.
03. ‘X-Ray Data Storage‘, Journal Club Presentation, 2004.
02. ‘Screen Capture Tutorial‘, Journal Club Presentation, 2004.
01. ‘Synchrotron Trip Preparations‘, Journal Club Presentation, 2003.

Updated: March 08, 2018.