xpang

Xiaodong Pang, Ph.D.

Postdoctoral Researcher
Dr. Huan-Xiang Zhou’s Group
Office – KLB 419
Email – xpang@fsu.edu

 

RESEARCH INTERESTS

Protein association

  • Kinetics of protein association
  • Mechanism of protein-protein association
  • Dock-and-coalesce mechanism of disorder protein association

Protein-ligand interactions studied by electronic structure calculations

Molecular Modeling and Peptide Inhibitor Design

  • Protein-ligand Docking and Screening were used to design peptide inhibitors for protein CypA and FKBP12.

A mathematic model for peptide inhibitor design was successfully developed through introducing the Hidden Markov Model.

EDUCATION
Ph. D  Fudan University, Shanghai, China  Physics  2005-2010
A.B.   Fudan University, Shanghai, China  Physics  2001-2005

PUBLICATIONS

(1)     X. Pang and H.-X. Zhou (2013). Poisson-Boltzmann calculations: van der Waals or molecular surface? Communications in Computational Physics. 13, 1-12.
(2)     X. Pang, K. H. Zhou, S. Qin, and H.-X. Zhou (2012). Prediction and dissection of widely-varying association rate constants of actin-binding proteins. PLoS Computational Biology. 8, e1002696
(3)     H.-X. Zhou, X. Pang, and L. Cai (2012). Rate constants and mechanisms of intrinsically disordered proteins binding to structured targets. Physical Chemistry Chemical Physics. 14, 10466-10476
(4)     X. Pang and H.-X. Zhou (2012). A common model for cytokine receptor activation: combined scissor-like rotation and self-rotation of receptor dimer induced by class I cytokine. PLoS Computational Biology. 8, e1002427
(5)     S. Qin, X. Pang, and H.-X. Zhou (2011). Automated prediction of protein association rate constants. Structure. 19, 1744-1751
(6)     X. Pang, S. Qin, and H.-X. Zhou (2011). Rationalizing 5,000-fold differences in receptor-binding rate constants of four cytokines. Biophysical Journal. 101, 1175-1183
(7)     X. Pang, M. J. Zhang, L. X. Zhou, F. Xie, H. Lu, W. He, S. B. Jiang, L. Yu and X. Y. Zhang. (2011) Discovery of a Potent Peptidic Cyclophilin A Inhibitor Trp-Gly-Pro. European Journal of Medicinal Chemistry. 46, 1701-1705
(8)     X. Pang, L. X. Zhou, M. J. Zhang, L. L. Zhang, L. N. Xu, F. Xie, L. Yu and X. Y. Zhang. (2010) A Mathematical Model for Peptide Inhibitor Design. Journal of Computational Biology. 17, 1081-1093

PRESENTATIONS
(1)   A common model for cytokine receptor activation: combined scissor-like rotation and self-rotation of receptor dimer induced by class I cytokine (poster). (2012) Biophysical Society 56th Annual Meeting, San Diego, California, USA