John Spear

Molecular Biophysics Graduate Student
Major Professor: Dr. Scott Stagg

Lab: 519 KLB (Kasha Laboratory Building)
E-mail: jms09z@my.fsu.edu


My research aims to understand the spatial organization of cargo molecules within a COPII coated vesicle by using cryo-EM to solve their three dimensional structures in vitro. The knowledge gained on this essential eukaryotic macromolecular complex will provide insight on the development of therapeutics designed to alleviate some on the autoimmune diseases associated with these proteins.

B.S. in Biochemistry, 2009, from the State University of New York (SUNY), College at Plattsburgh.

Undergraduate research award recipient 2008


  • FSU Life Sciences Symposium (2013). “Efficient COPII mediated trafficking of Kv1.3 relies upon a di-acidic motif”. (Tallahassee FL)
  • Frontiers In Macromolecular Imaging (2011). “Combining Mass Spectrometry, Cryo-EM, and Molecular modeling to generate a psuedo-atomic model of the COPII cage”. (Tallahassee FL)
  • Invited speaker at SUNY Plattsburgh Chemistry Seminar in November, 2011. (Plattsburgh NY).