Cocozaki crop2

Alexis Cocozaki

Molecular Biophysics Graduate Student
Major Professor: Dr. Hong Li

Lab: 210 KLB (Kasha Laboratory Building)


I work on structurally and functionally characterizing a ribonucleoprotein complex that uses a guide RNA to recognize and cleave complementary target RNA. The RNP complex is part of the CRISPR system of prokaryotic adaptive immunity. The CRISPR system consists of an array of small RNA sequences that are used to recognize and disable invader (plasmid or bacteriophage) DNA and/or RNA in a mechanism similar to RNAi in Eukaryotes. The system was very recently discovered and my work aims at understanding the the molecular details of how its protein players use guide RNA to recognize and destroy the invader RNA.

MS, Biology, American University of Beirut (2007)
BS, Medical Laboratory Technology, University of Balamand, Lebanon (2005)

2011-13 American Heart Association Pre-doctoral Fellowship

Structural Characterization of the CRISPR-Associated Cmr effector complex. Nucleic Acids meeting 2012.


Cocozaki AI, Ramia NF, Shao Y, Hale CR, Terns RM, Terns MP, Li H. Structure of the Cmr2 subunit of the CRISPR-Cas RNA silencing complex. Structure. 2012 Mar 7;20(3):545-53. PubMed PMID: 22405013.