“Targeting Ubiquitin Ligases: Hormones, Metabolites, and Drugs”
Ubiquitination is a widespread form of protein post-translational modification, which regulates diverse biological pathways in eukaryote cells. Ubiquitin ligases catalyze the final step of ubiquitin conjugation to specific substrates and are widely considered as the next generation therapeutic targets. Extensive efforts in discovering ubiquitin ligase inhibitors, however, failed in both academia and industry over the past two decades. This presentation will focus on how advances in plant biology have taught us an unexpected lesson in the “pharmacology” of protein ubiquitination, which points to a completely new direction in developing drugs harnessing the power of ubiquitin ligases.