Structural Biology/Biochemistry Seminar
11:15 am – 12:30 pm | 112 KLB
Tuesday, October 14, 2014
“Myosin light chain kinase – an enzyme on the move”
Professor, Dept. of Biochemistry and
University of Nevada, Reno
Hosted by Dr. Peter Fajer
I have worked in the field of muscle proteins since my doctoral work on the muscarinic acetylcholine receptor in the heart. After working on fluorescent nucleotide derivatives for studies on skeletal myosin structure and function, I moved on to try to understand the regulation of the smooth muscle myosin ATPase by phosphorylation of the regulatory light chain. The focus has been on structure-function relationships. This work is ongoing, as well as a new focus on structure-function relationships of smooth muscle myosin light chain kinase. This work has high relevance to several human diseases such as asthma, hypertension, and gastrointestinal disorders.
- Regulation of smooth muscle contraction.
- Solution kinetics of myosin-actin interactions.
- Single molecule kinetics of myosin-actin interactions.
- Single molecule interactions of myosin light chain kinase with cytoskeletal proteins.