Structural Biology/Biochemistry Seminar
Tuesday,
January 21, 2013
11:15 AM in 112 KLB

“Protein Stability in Living Cells”

 

Dr. Gary Pielak
Professor of Chemistry and Professor of Biochemistry & Biophysics,
University of North Carolina, Chapel Hill

Host: Dr. Andrew Miklos

http://www.chem.unc.edu/people/faculty/pielak/group/index.html

 

My students and I use the formalisms of equilibrium thermodynamics and the tools of molecular biology and biophysics to understand protein structure, stability, and function. Currently, our research focuses on three topics.

1. In-cell NMR. This new method allows us to obtain high resolution NMR data from proteins in living cells. This work involves quantifying the effects of macromolecular crowding on protein stability, dynamics and structure.

2. We are exploring the effects of macromolecular crowding on protein stability, dynamics and structure in vitro using both synthetic polymers and proteins as crowding agents.

3. We are studying the oxidative aggregation of the key protein involved in Parkinson’s disease, alpha-synuclein.